Syonell▼ (Valproate Semisodium) is licensed for the treatment of manic episodes in bipolar disorder when lithium is contraindicated or not tolerated
Syonell® ▼
(VALPROATE SEMISODIUM)
250mg & 500mg gastro-resistant tablets
Equivalent to 250mg
& 500mg Valproic Acid

▼ This medicinal product is subject to additional monitoring
• Syonell is bioequivalent to the originator product, Depakote®.1-4
• Prescribing Syonell by brand could reduce your drug spend.5,6
• Syonell is listed under Valproic Acid on formularies and GP databases.
• Prescribing Syonell by brand provides continuity for patients and the NHS.
Product Details

Syonell ▼ (VALPROATE SEMISODIUM)
250mg Gastro-Resistant Tablets
PIP Code | 4140760 |
Product Licence Number | PL 35507/0191 |
Lupin Product Code | 416225 |
Product Classification | POM |
Pack Size | 30 Tablets |
List Price | £4.55 |

Syonell ▼ (VALPROATE SEMISODIUM)
500mg Gastro-Resistant Tablets
PIP Code | 4140778 |
Product Licence Number | PL 35507/0192 |
Lupin Product Code | 416226 |
Product Classification | POM |
Pack Size | 30 Tablets |
List Price | £9.10 |
Please be aware the following statement has been removed from the SmPC section 4.4
NICE has advised that generic switching of valproate preparations is not normally recommended due to the clinical implications of possible variations in plasma concentrations.
This is based on the fact that the NICE clinical guideline for Bipolar disorder: assessment and management [CG185] does not include any restrictions regarding switching between generics.
Syonell Cost Savings
• Prescribing Syonell® offers a saving of 20% over the NHS Drug Tariff price, based on the originator product. 5,6
Brand | Strength | NHS List Price | Saving by prescribing Syonell® | Syonell® Discount |
---|---|---|---|---|
Depakote® | 250 mg 500 mg | £5.69 £11.37 | £1.14 £2.27 | 20% |
Belvo® | 250 mg 500 mg | £5.69 £11.37 | £1.14 £2.27 | 20% |
Drug Tariff | 250 mg 500 mg | £5.69 £11.37 | £1.14 £2.27 | 20% |
References: 1. Syonell 250mg Gastro-Resistant Tablets Summary of Product Characteristics. Lupin Healthcare UK Limited. 2. Syonell 500mg Gastro-Resistant Tablets Summary of Product Characteristics. Lupin Healthcare UK Limited. 3. Depakote 250mg Tablets Summary of Product Characteristics. https://www.medicines.org.uk/emc/product/6102/smpc. Accessed: March 2022. 4. Depakote 500mg Tablets Summary of Product Characteristics. https://www.medicines.org.uk/emc/product/6113/smpc. Accessed: March 2022. 5. Lupin Healthcare Limited. Data on File. LUP-VAL-01. 6. NHS BSA. Drug Tariff. https://www.nhsbsa.nhs.uk/pharmacies-gp-practices-and-appliancecontractors/drug-tariff. Accessed March 2022.
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UK-LUP-2208-00003 DOP: September 2022