Syonell - Lupin Healthcare Limited

Syonell▼ (Valproate Semisodium) is licensed to treat manic episodes in bipolar disorder only when there is no other effective or tolerated treatment

Syonell^® ▼(valproate semi-sodium) is contraindicated in pregnancy.

Syonell^® ▼ (Valproate Semi-Sodium) is contraindicated in women of childbearing potential aged under 55 years, unless two specialists independently consider and document that there is no other effective or tolerated treatment, and the conditions of the valproate pregnancy prevention programme (PPP) are fulfilled.

Syonell^® ▼ (Valproate Semi-Sodium) should not be used in female children, unless two specialists independently consider and document that there is no other effective or tolerated treatment.

Syonell^® ▼ (Valproate Semi-Sodium) should not be initiated in male children or men aged under 55 years unless two specialists independently consider and document that there is no other effective or tolerated treatment or the risk of infertility or potential risk of testicular toxicity are not applicable.

▼ This medicinal product is subject to additional monitoring

• Syonell is bioequivalent to the originator product, Depakote^®.^1-4

• Prescribing Syonell by brand could reduce your drug spend.^5,6

• Syonell is listed under Valproic Acid on formularies and GP databases.

• Prescribing Syonell by brand provides continuity for patients and the NHS.

Syonell ▼ (VALPROATE SEMISODIUM)
250mg Gastro-Resistant Tablets

PIP Code	4140760
Product Licence Number	PL 35507/0191
Lupin Product Code	416225
Product Classification	POM
Pack Size	30 Tablets
List Price	£4.55

Syonell ▼ (VALPROATE SEMISODIUM)
500mg Gastro-Resistant Tablets

PIP Code	4140778
Product Licence Number	PL 35507/0192
Lupin Product Code	416226
Product Classification	POM
Pack Size	30 Tablets
List Price	£9.10

To ensure the correct medication is prescribed for the patient, care must be taken not to confuse Syonell (valproate semisodium) with sodium valproate preparations. Please see Syonell SmPC section 4.4 for further information.

• Prescribing Syonell^® offers a saving of 20% over the NHS Drug Tariff price, based on the originator product.^5,6

Brand	Strength	NHS List Price	Saving by prescribing Syonell^®	Syonell^® Discount
Depakote®	250 mg 500 mg	£5.69 £11.37	£1.14 £2.27	20%
Belvo®	250 mg 500 mg	£5.69 £11.37	£1.14 £2.27	20%
Drug Tariff	250 mg 500 mg	£5.69 £11.37	£1.14 £2.27	20%

Syonell^® ▼(valproate semi-sodium) is contraindicated in pregnancy.

Syonell^® ▼ (Valproate Semi-Sodium) is contraindicated in women of childbearing potential aged under 55 years, unless two specialists independently consider and document that there is no other effective or tolerated treatment, and the conditions of the valproate pregnancy prevention programme (PPP) are fulfilled.

Syonell^® ▼ (Valproate Semi-Sodium) should not be used in female children, unless two specialists independently consider and document that there is no other effective or tolerated treatment.

Syonell^® ▼ (Valproate Semi-Sodium) should not be initiated in male children or men aged under 55 years unless two specialists independently consider and document that there is no other effective or tolerated treatment or the risk of infertility or potential risk of testicular toxicity are not applicable.

References: 1. Syonell 250mg Gastro-Resistant Tablets Summary of Product Characteristics. Lupin Healthcare UK Limited. 2. Syonell 500mg Gastro-Resistant Tablets Summary of Product Characteristics. Lupin Healthcare UK Limited. 3. Depakote 250mg Tablets Summary of Product Characteristics. https://www.medicines.org.uk/emc/product/6102/smpc. Accessed: April 2024. 4. Depakote 500mg Tablets Summary of Product Characteristics. https://www.medicines.org.uk/emc/product/6113/smpc. Accessed: April 2024. 5. NHS dm+d Browser. https://www.nhsbsa.nhs.uk/pharmacies-gp-practices-and-appliancecontractors/drug-tariff. Accessed April 2024. 6. NHS BSA. Drug Tariff. https://www.nhsbsa.nhs.uk/pharmacies-gp-practices-and-appliance-contractors/drug-tariff. Accessed April 2024.

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Syonell^® ▼

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