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Please be aware the following statement has been removed from the SmPC section 4.4
NICE has advised that generic switching of valproate preparations is not normally recommended due to the clinical implications of possible variations in plasma concentrations.
This is based on the fact that the NICE clinical guideline for Bipolar disorder: assessment and management [CG185] does not include any restrictions regarding switching between generics.
Syonell Cost Savings
•Prescribing Syonell® offers a saving of 20% over the NHS Drug Tariff price, based on the originator product. 5,6
Brand
Strength
NHS List Price
Saving by prescribing Syonell®
Syonell® Discount
Depakote®
250 mg
500 mg
£5.69
£11.37
£1.14
£2.27
20%
Belvo®
250 mg
500 mg
£5.69
£11.37
£1.14
£2.27
20%
Drug Tariff
250 mg
500 mg
£5.69
£11.37
£1.14
£2.27
20%
References: 1. Syonell 250mg Gastro-Resistant Tablets Summary of Product Characteristics. Lupin Healthcare UK Limited. 2. Syonell 500mg Gastro-Resistant Tablets Summary of Product Characteristics. Lupin Healthcare UK Limited. 3. Depakote 250mg Tablets Summary of Product Characteristics. https://www.medicines.org.uk/emc/product/6102/smpc. Accessed: March 2022. 4. Depakote 500mg Tablets Summary of Product Characteristics. https://www.medicines.org.uk/emc/product/6113/smpc. Accessed: March 2022. 5. Lupin Healthcare Limited. Data on File. LUP-VAL-01. 6. NHS BSA. Drug Tariff. https://www.nhsbsa.nhs.uk/pharmacies-gp-practices-and-appliancecontractors/drug-tariff. Accessed March 2022.
If you would like to get in touch, please contact us by the following:
Email to: information@lupin.com or customer services on 01565 751378
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